Exploring potential strategies to enhance memory and cognition in aging mice

Background: Aging population is rapidly expanding worldwide, and age-related cognitive impairments prove detrimental for achieving a better productive quality of life. Lack effective therapies impairment focuses attention on developing preventive strategies, such as nutritional interventions, cell environmental manipulations. The objective the present study was to explore comparative benefits potential memory-enhancing strategies like supplementation choline (Ch) docosahexaenoic acid (DHA) or administration human embryonic kidney stem conditioned media (HEK-CM) exposure enrichment (EE), that attenuates in aging mice. Methods: 12-month-old CF1 male mice were subdivided [n=6/group] into normal control (NAC), saline vehicle (SVC), Ch-DHA, EE, heat-inactivated HEK-CM (HIHEK-CM) mice. Spatial working reference memory assessed using an eight-arm radial maze test cognition novel object recognition (NORT). Results: Spatial decreased Aged exposed dietary Ch-DHA showed significant enhancement spatial learning tasks, compared same age-matched NAC treated committed significantly lesser errors attained higher percentage correct choices tasks. Moreover, testing NORT, number visits observed supplemented administered whereas EE groups greater familiar object, when HIHEK-CM groups, respectively. Conclusion: Supplementation treatment have [~ 20—30%] enhancing learning, aged mice, seems enhance only their short-term memory.